Research Areas: dementia , Alzheimer's disease. Marilyn Albert, Ph. Contact us or find a patient care location. Privacy Statement. Non-Discrimination Notice. All rights reserved. Another major aspect of patient-oriented research in the Alzheimer's Disease Research Center involves dementias other than Alzheimer's disease, including frontotemporal dementia and Lewy body dementia.
Many people with frontotemporal dementia or Lewy body dementia are being followed both longitudinally and in clinical trials by the Alzheimer's Disease Research Center. Neuroscience research laboratories at Mayo Clinic in Jacksonville, Fla.
In addition, the Mayo Clinic Alzheimer's Disease Research Center in Jacksonville has established a cohort of more than older African-Americans with normal cognition. MOAANS participants continue to be followed annually and have contributed to ongoing studies of the clinical, genetic, biomarker and neuroimaging characteristics that may help predict the risk of developing Alzheimer's disease and related dementias.
Basic science, or laboratory research, studies the cellular and molecular processes that cause nerve cells in the brain to stop functioning and die during aging, as well as the role of genes in affecting the risk of developing an aging-related disease. Investigators with the Alzheimer's Disease Research Center have been studying autopsy material from people followed in the research center to learn about the underlying pathological causes of the various dementia disorders, with emphasis on Alzheimer's disease and frontotemporal dementia.
In addition, the center's investigators are also able to learn about the underlying foundation of normal aging changes in the brain because of older participants with normal aging who volunteer for research projects. This helps researchers understand changes found in the brains of people with dementia-related diseases. Investigators with the Alzheimer's Disease Research Center have made significant progress in studying two proteins, amyloid and tau, that are strongly implicated in the development and progression of dementia in patients with Alzheimer's disease.
Research is progressing on a better understanding of the genetics, pathological development and treatment of people with frontotemporal dementia. Mayo Clinic researchers in Florida were among the first in the United States to identify novel genetic mutations in some families with frontotemporal dementia. In fact, the three most important dominantly inherited gene mutations that cause frontotemporal dementia were discovered at Mayo Clinic in Florida.
This work has led to animal models of the condition and a better understanding of its causes, while research about possible therapies continues. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Helena Chui, M. Stephen Strittmatter, M. Ronald C. Petersen, M. Todd E. Golde, M. Allan I. Levey, M. Marsel Mesulam, M. David A. Bennett, M. Andrew Saykin, PsyD.
Boustani, M. Indianapolis, Indiana Website Information line: Director's email. Russell H. Swerdlow, M. Linda Van Eldik, Ph. Charles D. Smith, M. Marilyn Albert, Ph. Neil Kowall, M. Bradley T. Hyman, M.
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